Bis(2-oxo-3-oxazolidinyl)phosphonic chloride , 97% , 68641-49-6

Synonym(s):
BOP-Cl;Phosphoric acid bis(2-oxooxazolidide) chloride

CAS NO.：68641-49-6

Empirical Formula: C6H8ClN2O5P

Molecular Weight: 254.56

MDL number: MFCD00010077

EINECS: 629-561-5

PRODUCT Properties

• Melting point: 191 °C (dec.)(lit.)
• Boiling point: 332.8±25.0 °C(Predicted)
• Density: 1.71±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: slightly sol CH2Cl2, MeCN, THF, DMF; dec H2O
• form: Crystalline Powder
• pka: -2.47±0.20(Predicted)
• color: White to off-white
• Water Solubility: Hydrolyzes with water.
• Sensitive: Moisture Sensitive
• BRN: 3654596
• InChI: InChI=1S/C6H8ClN2O5P/c7-15(12,8-1-3-13-5(8)10)9-2-4-14-6(9)11/h1-4H2
• InChIKey: KLDLRDSRCMJKGM-UHFFFAOYSA-N
• SMILES: P(N1CCOC1=O)(N1CCOC1=O)(Cl)=O
• CAS DataBase Reference: 68641-49-6(CAS DataBase Reference)

Description and Uses

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride is a reagent for activating carboxyl groups, converting acids to esters (including thioesters and phosphoesters), amides (including peptides and β-lactams), and anhydrides; reagent for kinetic resolution of racemic carboxylic acids and alcohols.

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride was used in the preparation of hexadepsipeptide.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H314
• Precautionary statements: P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
• Hazard Codes: C
• Risk Statements: 34
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: SZ5871000
• F: 10-21
• HazardClass: 8
• PackingGroup: II
• HS Code: 29349990
• Limited Quantities: 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)