1-Boc-3-hydroxyazetidine , 97% , 141699-55-0

Synonym(s):
tert-Butyl 3-hydroxyazetidine-1-carboxylate

CAS NO.：141699-55-0

Empirical Formula: C8H15NO3

Molecular Weight: 173.21

MDL number: MFCD04115305

EINECS: 628-534-5

PRODUCT Properties

• Melting point: 36-43 °C
• Boiling point: 253.7±33.0 °C(Predicted)
• Density: 1.184±0.06 g/cm3(Predicted)
• Flash point: >110℃
• storage temp.: 2-8°C
• solubility: soluble in Methanol
• form: Solid
• pka: 14.16±0.20(Predicted)
• color: White to light yellow
• InChI: InChI=1S/C8H15NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h6,10H,4-5H2,1-3H3
• InChIKey: XRRXRQJQQKMFBC-UHFFFAOYSA-N
• SMILES: N1(C(OC(C)(C)C)=O)CC(O)C1
• CAS DataBase Reference: 141699-55-0(CAS DataBase Reference)

Description and Uses

1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H315-H318-H335
• Precautionary statements: P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• TSCA: No
• HazardClass: IRRITANT
• HS Code: 29339900