Benztropine mesylate , ≥98% , 132-17-2
Synonym(s):
Benzatropine mesylate;Benzatropine, Cogentin;Benzotropine mesylate;Benztropine mesylate;Benztropine methanesulfonate
CAS NO.：132-17-2
Empirical Formula: C22H29NO4S
Molecular Weight: 403.53
MDL number: MFCD00074784
EINECS: 205-048-8
| Pack Size | Price | Stock | Quantity |
| 1G | RMB134.40 | In Stock |
|
| 5G | RMB498.40 | In Stock |
|
| 25g | RMB2392.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 135 °C(lit.) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| Water Solubility | Soluble in water (81 mg/ml at 25°C), DMSO (50 mg/ml at 25°C), ethanol (81 mg/ml at 25°C), and ether (very slightly). |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | InChI=1/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+; |
| InChIKey | CPFJLLXFNPCTDW-BWSPSPBFNA-N |
| SMILES | C(O[C@@H]1C[C@@]2([H])N(C)[C@]([H])(CC2)C1)(C1=CC=CC=C1)C1=CC=CC=C1.S(=O)(=O)(O)C |&1:2,4,8,r| |
| LogP | 4.962 (est) |
| CAS DataBase Reference | 132-17-2(CAS DataBase Reference) |
Description and Uses
Benztropine mesylate (132-17-2) is a centrally acting M1?muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1?Also inhibits the dopamine transporter (Ki=160 nM).2?Benztropine mesylate enhances remyelination and significantly decreases clinical severity in the experimental autoimmune encephalomyelitis model of relapsing-remitting multiple sclerosis alone or in combination with immunosuppressive agents.3?Inhibits hepatitis C virus infection.4
Benzotropine methanesulfonate is used to treat the symptoms of Parkinson?s disease and is currently in clincial trials for chronic back pain. It shows anti-muscarinic effects comparable to Atropine, and also demonstrates competitive anti-nicotinic action at the nAChR (nicotinic acetylcholine receptor).
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H302-H311+H331 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P311 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | YM3150000 |
| HazardClass | 6.1 |
| HS Code | 2939800000 |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
