PemetrexedDisodiumSaltHeptahydrate , 99% , 357166-29-1

Synonym(s):
Pemetrexed disodium heptahydrate

CAS NO.：357166-29-1

Empirical Formula: C20H19N5Na2O6.7(H2O)

Molecular Weight: 597

MDL number: MFCD09029394

EINECS: 639-569-0

PRODUCT Properties

• storage temp.: 2-8°C
• solubility: H2O: soluble30mg/mL, clear
• form: powder
• color: white to beige
• Water Solubility: H2O: 30mg/mL, clear
• Stability: Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
• InChIKey: AEZRDYKQLPDYEH-YTCXBBKHNA-N
• SMILES: C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r|

Description and Uses

Pemetrexed Disodium Heptahydrate(357166-29-1) is a multi-targeted antifolate with antitumor activity. Its formal name is N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki= 109 nM), dihydrofolate reductase (Ki= 7 nM), glycinamide ribonucleotide formyltransferase (Ki= 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki= 3.6 μM). It is a clinically useful anticancer agent. Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas. Activation of AMPK is associated with pemetrexed resistance. Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H315-H319-H341-H360FD-H372
• Precautionary statements: P202-P260-P264-P302+P352-P305+P351+P338-P308+P313
• target organs: Blood,Immune system,Testes
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29335990
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Muta. 2; Repr. 1A; Skin Irrit. 2; STOT RE 1