PemetrexedDisodiumSaltHeptahydrate , 99% , 357166-29-1
Synonym(s):
Pemetrexed disodium heptahydrate
CAS NO.：357166-29-1
Empirical Formula: C20H19N5Na2O6.7(H2O)
Molecular Weight: 597
MDL number: MFCD09029394
EINECS: 639-569-0
| Pack Size | Price | Stock | Quantity |
| 1g | RMB132.80 | In Stock |
|
| 5g | RMB535.20 | In Stock |
|
| 25g | RMB2142.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | 2-8°C |
| solubility | H2O: soluble30mg/mL, clear |
| form | powder |
| color | white to beige |
| Water Solubility | H2O: 30mg/mL, clear |
| Stability: | Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month. |
| InChIKey | AEZRDYKQLPDYEH-YTCXBBKHNA-N |
| SMILES | C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r| |
Description and Uses
Pemetrexed Disodium Heptahydrate(357166-29-1) is a multi-targeted antifolate with antitumor activity. Its formal name is N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki?= 109 nM), dihydrofolate reductase (Ki?= 7 nM), glycinamide ribonucleotide formyltransferase (Ki?= 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki?= 3.6 μM). It is a clinically useful anticancer agent. Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas. Activation of AMPK is associated with pemetrexed resistance. Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.
Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315-H319-H341-H360FD-H372 |
| Precautionary statements | P202-P260-P264-P302+P352-P305+P351+P338-P308+P313 |
| target organs | Blood,Immune system,Testes |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29335990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Muta. 2 Repr. 1A Skin Irrit. 2 STOT RE 1 |
