Tenofovirdisoproxilfumarate , 98% , 202138-50-9

Synonym(s):
Bis(POC)PMPA fumarate;Bis{[(Isopropoxycarbonyl)oxy]methyl} ({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonate fumarate;Tenofovir disoproxil fumarate

CAS NO.：202138-50-9

Empirical Formula: C23H34N5O14P

Molecular Weight: 635.52

MDL number: MFCD08141829

EINECS: 687-766-5

PRODUCT Properties

• Melting point: 113-115°C
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: powder
• color: white to beige
• Water Solubility: H2O: 3mg/mL, clear (warmed)
• InChIKey: VCMJCVGFSROFHV-PSMOUDLHNA-N
• SMILES: C(/C(=O)O)=C\C(=O)O.C(N1C=NC2C(=NC=NC1=2)N)[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C |&1:19,r|
• CAS DataBase Reference: 202138-50-9(CAS DataBase Reference)

Description and Uses

Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir . Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.

Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.

Safety

• Symbol(GHS): GHS05
• Signal word: Danger
• Hazard statements: H318-H412
• Precautionary statements: P280-P305+P351+P338-P310-P273-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• HS Code: 2933599550
• Hazardous Substances Data: 202138-50-9(Hazardous Substances Data)