6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one , 97% , 1016636-76-2

CAS NO.：1016636-76-2

Empirical Formula: C13H13BrClN3O

Molecular Weight: 342.62

MDL number: MFCD13181208

EINECS: 800-433-2

PRODUCT Properties

• Melting point: 190-192°C
• Boiling point: 468.4±45.0 °C(Predicted)
• Density: 1.645±0.06 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
• form: Solid
• pka: -0.61±0.20(Predicted)
• color: White
• InChI: InChI=1S/C13H13BrClN3O/c1-7-9-6-16-13(15)17-11(9)18(12(19)10(7)14)8-4-2-3-5-8/h6,8H,2-5H2,1H3
• InChIKey: HJQCAEDIUJXGCQ-UHFFFAOYSA-N
• SMILES: C1(Cl)=NC=C2C(C)=C(Br)C(=O)N(C3CCCC3)C2=N1

Description and Uses

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is a pharmaceutical intermediate that can be used to synthesize Palbociclib, an inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 for the treatment of breast cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317-H319
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN2811