A2324112
p-Cresol , 98% , 106-44-5
Synonym(s):
p-Cresol;4-Methylphenol;4-Methylphenol solution;p-Cresol;p-Cresol solution
CAS NO.：106-44-5
Empirical Formula: C7H8O
Molecular Weight: 108.14
MDL number: MFCD00002376
EINECS: 203-398-6
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 32-34 °C(lit.) |
| Boiling point: | 202 °C(lit.) |
| Density | 1.034 g/mL at 25 °C(lit.) |
| vapor density | 3.72 (vs air) |
| vapor pressure | 1 mm Hg ( 20 °C) |
| refractive index | nD20 1.5395 |
| FEMA | 2337 | P-CRESOL |
| Flash point: | 193 °F |
| storage temp. | Store below +30°C. |
| solubility | 20g/l |
| pka | 10.17(at 25℃) |
| form | Crystalline Solid or Liquid |
| color | Colorless to light yellow, may darken on exposure to light |
| Specific Gravity | 1.0341 (20/4℃) |
| Odor | at 0.10 % in dipropylene glycol. phenolic narcissus animal mimosa |
| Odor Threshold | 0.000054ppm |
| Odor Type | phenolic |
| biological source | synthetic |
| explosive limit | 1%(V) |
| Water Solubility | 20 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| Merck | 14,2579 |
| JECFA Number | 693 |
| BRN | 1305151 |
| Henry's Law Constant | 6.17 at 20.00 °C, 9.31 at 25.00 °C (dynamic equilibrium system-GC, Feigenbrugel et al., 2004a) |
| Exposure limits | ACGIH TLV-TWA:20 mg/m3,Inhalable fraction and vapor OSHA PEL-TWA:5 ppm (22 mg/m3) NIOSH REL-TWA:2.3 ppm (10 mg/m3);IDLH:250 ppm |
| Dielectric constant | 5.6（21.0℃） |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. Air and light-sensitive. Hygroscopic. |
| Cosmetics Ingredients Functions | ANTIMICROBIAL PERFUMING |
| Cosmetic Ingredient Review (CIR) | p-Cresol (106-44-5) |
| InChI | 1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3 |
| InChIKey | IWDCLRJOBJJRNH-UHFFFAOYSA-N |
| SMILES | Cc1ccc(O)cc1 |
| LogP | 1.94 |
| Surface tension | 35.47mN/m at 298.15K |
| CAS DataBase Reference | 106-44-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 4-methyl-(106-44-5) |
| EPA Substance Registry System | p-Cresol (106-44-5) |
Description and Uses
p-Cresol is utilized in the production of artificial resins, liquid crystal intermediates, disinfectants, fumigants, and as an industrial solvent. It is also involved in the manufacturing of Bupranolol, a non-selective beta blocker.
Safety
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301+H311-H314-H370-H372-H373-H351-H401-H412 |
| Precautionary statements | P501-P273-P260-P270-P202-P201-P264-P280-P308+P311-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P405 |
| Hazard Codes | T,Xi |
| Risk Statements | 24/25-34-39/23/24/25-23/24/25 |
| Safety Statements | 36/37/39-45-36/37 |
| RIDADR | UN 3455 6.1/PG 2 |
| OEB | B |
| OEL | TWA: 2.3 ppm (10 mg/m3) |
| WGK Germany | 1 |
| RTECS | GO6475000 |
| F | 8 |
| Autoignition Temperature | 555 °C |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29071200 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Oral Aquatic Chronic 3 Eye Dam. 1 Skin Corr. 1B |
| Hazardous Substances Data | 106-44-5(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 1.8 g/kg (Deichmann, Witherup) |
| REACH Registrations | Active |
| Limited Quantities | 0.5 Kg (solid) |
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
