Chymostatin , ≥95% , 9076-44-2

Synonym(s):
[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-α-[2-amidohexahydro-4(S)-pyrimidyl]-(S)-glycyl-[A = Leu; B = Val; or C = Ile]-phenylalaninal;Chymostatin;Chymostatin - CAS 9076-44-2 - Calbiochem;N-(N_α-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)

CAS NO.：9076-44-2

Empirical Formula: C92H121N21O18

Molecular Weight: 1809.08

MDL number: MFCD00071059

EINECS: 618-642-0

PRODUCT Properties

• Melting point: 205 °C
• storage temp.: -20°C
• solubility: DMSO: 10 mM Stock solutions stable for months at −20 °C.
• form: White to slightly yellow solid or powder
• color: White or off-white
• biological source: microbial
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Description and Uses

Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase-like serine proteases. It potently inhibits chymotrypsin and chymase (K_i = 9.36 and 13.1 nM, respectively) while less effectively blocking the activity of cathepsins, papain, and leukocyte elastase. It is without effect on trypsin, thrombin, plasmin, pepsin, and kallikrein.

Chymostatin has been used in a study that determined that molecular calculations are useful for evaluating the interactions between ligands, including inhibitors and homologous enzymes, in docking models. Chymostatin has also been used in a study to investigate the norovirus protease as an attractive target for antiviral drug development.

Safety

• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• RTECS: GC3047700
• F: 10-21