Climbazol , Analysis standard , 38083-17-9
Synonym(s):
1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one
CAS NO.：38083-17-9
Empirical Formula: C15H17ClN2O2
Molecular Weight: 292.76
MDL number: MFCD00055505
EINECS: 253-775-4
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB636.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 96-100°C |
| Boiling point: | 447.5±40.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.54 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Insoluble in water |
| form | Solid |
| pka | 5.66±0.22(Predicted) |
| color | White to Almost white |
| Water Solubility | 58mg/L at 25℃ |
| BRN | 618020 |
| Major Application | agriculture environmental |
| Cosmetics Ingredients Functions | ANTIMICROBIAL PRESERVATIVE ANTI-SEBORRHEIC |
| InChI | 1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 |
| InChIKey | OWEGWHBOCFMBLP-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2ccnc2 |
| LogP | 3.83 at 25℃ |
| CAS DataBase Reference | 38083-17-9(CAS DataBase Reference) |
Description and Uses
(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302-H410 |
| Precautionary statements | P301+P312+P330 |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 |
| WGK Germany | 3 |
| RTECS | EL7085000 |
| HS Code | 29332900 |
| Storage Class | 13 - Non Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 |
