Chlorpheniramine Maleate , ≥99% , 113-92-8

Synonym(s):
(±)-Chlorpheniramine maleate salt;Chlorpheniramine maleate solution

CAS NO.：113-92-8

Empirical Formula: C20H23ClN2O4

Molecular Weight: 390.86

MDL number: MFCD00069225

EINECS: 204-037-5

PRODUCT Properties

• Melting point: 130-135 °C (lit.)
• alpha: -1～+1°(D/20℃)(c=5,DMF)
• Density: 1.1984 (rough estimate)
• refractive index: 1.6800 (estimate)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Freely soluble in water, soluble in ethanol (96 per cent)
• form: Solid
• color: White to Almost white
• Odor: odorless
• PH: 4.0～5.5 (10g/l, 25℃)
• Water Solubility: 1-5 g/100 mL at 21 ºC
• Merck: 14,2180
• BCS Class: 3/1
• InChI: 1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: DBAKFASWICGISY-BTJKTKAUSA-N
• SMILES: CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
• LogP: 3.389 (est)
• EPA Substance Registry System: Chlorpheniramine maleate (113-92-8)

Description and Uses

Chlorpheniramine is a histamine H₁ receptor antagonist with an IC₇₅ value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD₅₀ = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED_100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

(±)-Chlorpheniramine maleate salt has been used:

• as H1 receptor antagonist to determine the receptor function
• to block the effect of compound 48/80 on plasma IGF-I
• as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• PPE: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• Hazard Codes: T,F
• Risk Statements: 25-39/23/24/25-23/24/25-11
• Safety Statements: 36/37/39-45-36/37-16
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: US6504000
• TSCA: TSCA listed
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29333990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral
• Toxicity: LD50 orally in mice: 162 mg/kg (Smith)