cefazolin sodium salt , ≥97.0%(HPLC) , 27164-46-1

CAS NO.：27164-46-1

Empirical Formula: C14H15N8NaO4S3

Molecular Weight: 478.5

MDL number: MFCD00056883

EINECS: 248-278-4

PRODUCT Properties

• Melting point: 190 °C
• refractive index: 20 ° (C=10, H2O)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H₂O: 50 mg/mL, clear, colorless
• form: crystalline powder
• color: White to Off-White
• optical activity: -67.2°(C=0.01g/ml DMF)
• Sensitive: Light Sensitive
• Merck: 14,1917
• BRN: 3585038
• Stability: Stable, but may be heat sensitive - store in cool conditions. May discolour upon exposure to light - store in the dark. Incompatible with strong oxidizing agents.
• InChIKey: LJIOGPYKTPCRAP-MVOALHSDNA-N
• SMILES: C(C1=C(CS[C@]2([H])[C@H](NC(=O)CN3N=NN=C3)C(=O)N12)CSC1=NN=C(C)S1)(=O)O.[NaH] |&1:5,7,r|
• LogP: 1.133 (est)
• CAS DataBase Reference: 27164-46-1(CAS DataBase Reference)

Description and Uses

Cefazolin was synthesized by Fujisawa Pharmaceutical Co. in 1969. It was the first of the cephem antibiotics to introduce a thiadiazolylthiomethyl group at the 3 position and a tetrazole group at the 7 position in the side chain. Cefazolin is a parenteral cephem antibiotic showing better activity against gramnegative bacteria than cephalothin or cephaloridine. Its bactericidal activity, tissue distribution, and urinary excretion are excellent and it has wide clinical use.

Semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. An antibacterial

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P280-P342+P311
• Hazard Codes: Xn,Xi
• Risk Statements: 42/43-36/37/38-20/21/22
• Safety Statements: 22-36/37-36-26
• WGK Germany: 2
• RTECS: XI0390000
• HS Code: 29349990
• Toxicity: LD50 in mice, rats (mg/kg): 3.9, 3.18 i.v.; 6.2, 7.4 i.p. (Birkhead)