A2613251
RO20-1724 , ≥99% , 29925-17-5
Synonym(s):
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone;Ro 20-1724;Ro-20-1724 - CAS 29925-17-5 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB127.20 | In Stock |
|
| 25mg | RMB399.20 | In Stock |
|
| 100mg | RMB1199.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 125-127° |
| Boiling point: | 483.8±25.0 °C(Predicted) |
| Density | 1.099±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | ethanol: 7 mg/mL |
| form | solid |
| pka | 14.54±0.40(Predicted) |
| color | White |
| biological source | synthetic (organic) |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. |
| CAS DataBase Reference | 29925-17-5(CAS DataBase Reference) |
Description and Uses
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
