Diltiazem HCl , ≥98.0% , 33286-22-5

Synonym(s):
(+)-cis-Diltiazem hydrochloride;(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride;CRD-401;Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem;L-Type Calcium Channel Blocker II

CAS NO.：33286-22-5

Empirical Formula: C22H27ClN2O4S

Molecular Weight: 450.98

MDL number: MFCD00069252

EINECS: 251-443-3

PRODUCT Properties

• Melting point: 212-214 °C
• alpha: D24 +98.3 ± 1.4° (c = 1.002 in methanol)
• Density: 1.30 g/cm3
• refractive index: 118 ° (C=1, H2O)
• Flash point: 2℃
• storage temp.: 2-8°C
• solubility: Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.
• form: Powder
• color: White to off-white
• PH: pH (10g/l, 25℃) : 4.3～5.3
• Water Solubility: soluble
• Merck: 13,3226
• BRN: 4228706
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: 33286-22-5(CAS DataBase Reference)
• EPA Substance Registry System: 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)- (33286-22-5)

Description and Uses

Diltiazem HCl (33286-22-5) is a?non-dihydropyridine-type blocker of L-type Ca2+ channels.1,2 Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells.3?Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons.4 Clinically useful antihypertensive agent.5?Cell permeable.

Peripheral Vasodilator

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,Xi,F
• Risk Statements: 22-40-36/37/38-36-20/21/22-11
• Safety Statements: 36-45-36/37-26-16
• RIDADR: 3249
• WGK Germany: 3
• RTECS: DL0310000
• F: 8-10
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29349990
• Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)