2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl , 98% , 213697-53-1

Synonym(s):
2-Dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl

CAS NO.：213697-53-1

Empirical Formula: C26H36NP

Molecular Weight: 393.54

MDL number: MFCD02183572

EINECS: 606-749-5

PRODUCT Properties

• Melting point: 121-124 °C(lit.)
• Boiling point: 539.6±43.0 °C(Predicted)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• pka: 5.04±0.18(Predicted)
• form: crystal
• color: white
• Water Solubility: Insoluble
• Sensitive: Air Sensitive
• InChI: InChI=1S/C26H36NP/c1-27(2)25-19-11-9-17-23(25)24-18-10-12-20-26(24)28(21-13-5-3-6-14-21)22-15-7-4-8-16-22/h9-12,17-22H,3-8,13-16H2,1-2H3
• InChIKey: ZEMZPXWZVTUONV-UHFFFAOYSA-N
• SMILES: C1(C2=CC=CC=C2P(C2CCCCC2)C2CCCCC2)=CC=CC=C1N(C)C
• CAS DataBase Reference: 213697-53-1(CAS DataBase Reference)

Description and Uses

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• TSCA: No
• HazardClass: AIR SENSITIVE
• HS Code: 29310099