A3153912
1,3-Dioxlane , 99.5%, including ~ 75ppMBHT stabilizer , 646-06-0
Synonym(s):
1,3-Dioxacyclopentane, Formaldehyde ethylene acetal, Ethylene glycol methylene ether;1,3-Dioxolane;Ethylene glycol methylene ether;Formaldehyde ethylene acetal
CAS NO.：646-06-0
Empirical Formula: C3H6O2
Molecular Weight: 74.08
MDL number: MFCD00003207
EINECS: 211-463-5
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | -95 °C (lit.) |
| Boiling point: | 75-76 °C/1.013 hPa |
| Density | 1.06 g/mL at 25 °C (lit.) |
| vapor density | 2.6 (vs air) |
| vapor pressure | 70 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | 35 °F |
| storage temp. | Store at <= 20°C. |
| solubility | 1000g/l soluble |
| form | Liquid |
| color | White to off-white |
| Odor | Mild, ethereal odor |
| explosive limit | 2.1-20.5%(V) |
| Water Solubility | SOLUBLE |
| BRN | 102453 |
| Exposure limits | ACGIH: TWA 20 ppm |
| Stability: | Below 4°C |
| InChIKey | WNXJIVFYUVYPPR-UHFFFAOYSA-N |
| LogP | -0.37 at 20℃ |
| Surface tension | 32.55mN/m at 298.15K |
| CAS DataBase Reference | 646-06-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,3-Dioxolane(646-06-0) |
| EPA Substance Registry System | 1,3-Dioxolane (646-06-0) |
Description and Uses
Dioxolane is a water-white liquid. Molecularweight= 74.09; Boiling point = 74℃; Flash point = 2℃(oc). Hazard Identification (based on NFPA-704 M RatingSystem): Health 2, Flammability 4, Reactivity 2. Soluble in water.
1,3-Dioxolane is an intermediate for the preparation of Acyclovir (A192400). Also, 1,3-Dioxolane is used in the synthesis of new Vandetanib (V097100) analogs.
Safety
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H319-H360 |
| Precautionary statements | P201-P210-P305+P351+P338-P308+P313 |
| Hazard Codes | F |
| Risk Statements | 11 |
| Safety Statements | 16 |
| RIDADR | UN 1166 3/PG 2 |
| WGK Germany | 1 |
| RTECS | JH6760000 |
| Autoignition Temperature | 525 °F |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29329970 |
| Hazardous Substances Data | 646-06-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 3000 mg/kg LD50 dermal Rabbit 9074 mg/kg |
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
