A3155812
Di-tert-butyl dicarbonate , 96% , 24424-99-5
Synonym(s):
Boc anhydride;Boc2O;Di-tert-butyl pyrocarbonate;Di-tert-butyl dicarbonate;Di-tert-butyl dicarbonate, Di-tert-butyl pyrocarbonate
CAS NO.：24424-99-5
Empirical Formula: C10H18O5
Molecular Weight: 218.25
MDL number: MFCD00008805
EINECS: 246-240-1
| Pack Size | Price | Stock | Quantity |
| 25g | RMB23.20 | In Stock |
|
| 100G | RMB39.20 | In Stock |
|
| 500G | RMB148.00 | In Stock |
|
| 5kg | RMB1199.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 23 °C (lit.) |
| Boiling point: | 56-57 °C/0.5 mmHg (lit.) |
| Density | 0.95 g/mL at 25 °C (lit.) |
| vapor pressure | 3.85Pa at 25℃ |
| refractive index | n |
| Flash point: | 99 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Low Melting Crystalline Solid |
| color | White |
| Specific Gravity | 0.950 |
| Water Solubility | Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water. |
| Sensitive | Moisture Sensitive |
| BRN | 1911173 |
| Stability: | Acid Sensitive |
| InChIKey | DYHSDKLCOJIUFX-UHFFFAOYSA-N |
| LogP | 1.87 at 25℃ |
| CAS DataBase Reference | 24424-99-5(CAS DataBase Reference) |
| EPA Substance Registry System | Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5) |
Description and Uses
Di-tert-butyl dicarbonate (Boc2O) is a widely used reagent for introducing protecting groups in peptide synthesis. It plays an important role in the preparation of 6-acetyl-1,2,3,4-tetrahydropyridine by reacting with 2-piperidone. It serves as a protecting group used in solid phase peptide synthesis.
Safety
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H226-H315-H317-H318-H330-H335 |
| Precautionary statements | P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T+,T,F,Xi,F+ |
| Risk Statements | 11-19-26-36/37/38-43-10-40 |
| Safety Statements | 16-26-28-36/37-45-7/9-37/39-24-36/37/39-33 |
| RIDADR | UN 2929 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | HT0230000 |
| F | 4.4-10-21 |
| Autoignition Temperature | 460 °C |
| Hazard Note | Flammable/Irritant/Very Toxic |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | I |
| HS Code | 29209010 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) |
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
