Cynarin , Analysis standard product, 95% , 30964-13-7

Synonym(s):
Cynarin;1,3-Dicaffeoylquinic acid;1,5-Dicaffeoylquinic acid;Cynarine;1,5-DQA

CAS NO.：30964-13-7

Empirical Formula: C25H24O12

Molecular Weight: 516.45

MDL number: MFCD00075714

EINECS: 214-655-7

PRODUCT Properties

• Melting point: 225-227°
• alpha: D25 -59° (c = 2 in methanol)
• Boiling point: 819.9±65.0 °C(Predicted)
• Density: 1?+-.0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: methanol: soluble5mg/mL, clear, light yellow to yellow
• pka: 2.58±0.50(Predicted)
• form: Solid
• color: faint yellow to yellow
• Stability: Hygroscopic
• InChIKey: YDDUMTOHNYZQPO-GCBRTHAASA-N
• SMILES: [C@@]1(OC(=O)C=CC2=CC=C(O)C(O)=C2)(C(O)=O)C[C@@H](O)[C@H](O)[C@H](OC(=O)C=CC2=CC=C(O)C(O)=C2)C1
• LogP: 1.640 (est)
• CAS DataBase Reference: 30964-13-7(CAS DataBase Reference)

Description and Uses

1,3-Dicaffeoylquinic acid is a polyphenol that has been found in C. scolymus. It decreases the expression and protein levels of inducible nitric oxide synthase (iNOS) when used at a concentration of 10 μM in human coronary artery smooth muscle cells (HCASMCs) treated with a cytokine mixture. 1,3-Dicaffeoylquinic acid decreases protein levels of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F1 murine melanocytes. It inhibits melanogenesis in B16F1 cells and decreases tyrosinase activity in cell lysates when used at a concentration of 25 μM. 1,3-Dicaffeoylquinic acid (20 and 40 μM) reduces triglyceride levels in sodium oleate-induced hyperlipidemic HepG2 cells compared to hyperlipidemic control cells.

Cynarin is used on MDR cells in anti-cancer therapy as an inhibitor of P-glycoprotein-mediated transport.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29182900