Diethyl (bromodifluoromethyl)phosphonate , 97% , 65094-22-6

Synonym(s):
(Bromodifluoromethyl)phosphonic acid diethyl ester

CAS NO.：65094-22-6

Empirical Formula: C5H10BrF2O3P

Molecular Weight: 267.01

MDL number: MFCD00069118

PRODUCT Properties

• Boiling point: 40-41 °C/0.05 mmHg (lit.)
• Density: 1.503 g/mL at 25 °C (lit.)
• refractive index: n20/D 1.417(lit.)
• Flash point: >230 °F
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: Chloroform, Ethyl Acetate
• form: liquid
• Specific Gravity: 1.503
• color: colorless
• Water Solubility: Not miscible or difficult to mix in water.
• BRN: 1944045
• InChI: InChI=1S/C5H10BrF2O3P/c1-3-10-12(9,11-4-2)5(6,7)8/h3-4H2,1-2H3
• InChIKey: QRADKVYIJIAENZ-UHFFFAOYSA-N
• SMILES: P(=O)(OCC)(OCC)C(F)(F)Br
• CAS DataBase Reference: 65094-22-6(CAS DataBase Reference)

Description and Uses

Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313
• Hazard Codes: Xi
• Risk Statements: 21/22-36/38-38-36
• Safety Statements: 26-36/37/39-60-37-23
• RIDADR: 3278
• WGK Germany: 3
• Hazard Note: Irritant
• TSCA: No
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• PackingGroup: III
• HS Code: 29319090