PRODUCT Properties
| Melting point: | 37-40 °C (lit.) |
| Boiling point: | 108 °C |
| Density | 1.384±0.06 g/cm3(Predicted) |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| form | powder to lump |
| color | Light yellow to Brown to Dark green |
| FreezingPoint | 31.0 to 34.0 ℃ |
| CAS DataBase Reference | 1544-86-1(CAS DataBase Reference) |
Description and Uses
4-(Difluoromethoxy)nitrobenzene is an industrial chemical that can be used to make 4-fluoro-3-pyridinol (F3P), a compound that has potential as a new drug for the treatment of cancer. The synthesis of F3P begins with the reaction of 4-(difluoromethoxy)nitrobenzene and potassium hydroxide in methanol, which yields 4-fluoro-3-hydroxypyridine. This product is then reacted with ammonia gas and pyridine to yield F3P. The final step involves heating the product at high temperature with nitric acid, which yields nitrobenztriazole.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P280a-P304+P340-P405-P501a-P261-P305+P351+P338 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37 |
| RIDADR | 3276 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29049090 |
