Doramapimod , ≥99% , 285983-48-4

Synonym(s):
Doramapimod, BIRB796, 1-(5- tert-Butyl-2- p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII;Doramapimod, BIRB796, 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea, JNK Inhibitor XVII;p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem

CAS NO.：285983-48-4

Empirical Formula: C31H37N5O3

Molecular Weight: 527.66

MDL number: MFCD09752957

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 142-143 °C
• Boiling point: 631.6±55.0 °C(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
• form: solid
• pka: 13.47±0.70(Predicted)
• color: White or off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Description and Uses

Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1?(IC50=18 nM). Displays anti-inflammatory activity2?but differential effects on inflammatory genes3. Cell permeable.

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H335-H302+H312+H332-H315
• Precautionary statements: P301+P312-P302+P352-P305+P351+P338
• HS Code: 2934999090