D4476 , ≥98% , 301836-43-1

Synonym(s):
4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide;Casein Kinase I Inhibitor, D4476 - CAS 301836-43-1 - Calbiochem;CK1 Inhibitor, 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

CAS NO.：301836-43-1

Empirical Formula: C23H18N4O3

Molecular Weight: 398.41

MDL number: MFCD09037526

PRODUCT Properties

• Boiling point: 675.0±55.0 °C(Predicted)
• Density: 1.338±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ~20mg/mL
• pka: 10.16±0.10(Predicted)
• form: solid
• color: light yellow

Description and Uses

D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC₅₀ = 200 nM from S. pombe, 300 nM for CK1δ). It is a less effective inhibitor of PKD1 (IC₅₀ = 9.1 μM) and p38α MAPK (IC₅₀ = 5.8 μM), and only weakly affects the activities of a panel of kinases tested. D 4476 blocks CK1-mediated phosphorylation of FOXO1a, RhoB, and p53. As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
• WGK Germany: 3