Dovitinib (TKI-258, CHIR-258) , ≥99% , 405169-16-6
CAS NO.：405169-16-6
Empirical Formula: C21H21FN6O
Molecular Weight: 392.43
MDL number: MFCD11870802
EINECS: 1308068-626-2
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB724.00 | In Stock |
|
| 50MG | RMB2399.20 | In Stock |
|
| 250MG | RMB4799.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Density | 1.386 |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 30 mg/ml). |
| form | solid |
| pka | 9.44±0.70(Predicted) |
| color | Yellow-green |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) |
| InChIKey | PIQCTGMSNWUMAF-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(F)=CC=C2)C(N)=C(C2NC3=CC(N4CCN(C)CC4)=CC=C3N=2)C1=O |
| CAS DataBase Reference | 405169-16-6 |
Description and Uses
Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell culture and in whole animals. Dovitinib selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
