4-(Difluoromethoxy)-3-hydroxybenzaldehyde , 95% , 151103-08-1

Synonym(s):
3-Hydroxy-4-difluoromethoxybenzaldehyde

CAS NO.：151103-08-1

Empirical Formula: C8H6F2O3

Molecular Weight: 188.13

MDL number: MFCD04406687

EINECS: 687-745-0

PRODUCT Properties

• Melting point: 85-90°C
• Boiling point: 280.6±35.0 °C(Predicted)
• Density: 1.395±0.06 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: Solid
• pka: 7.85±0.35(Predicted)
• color: White
• InChI: InChI=1S/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H
• InChIKey: ZLIKNROJGXXNJG-UHFFFAOYSA-N
• SMILES: C(=O)C1=CC=C(OC(F)F)C(O)=C1
• CAS DataBase Reference: 151103-08-1(CAS DataBase Reference)

Description and Uses

4-Difluoromethoxy-3-hydroxybenzaldehyde is an organofluorine compound, mainly used as an intermediate in organic synthesis. It is used in the synthesis of the impurity N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide isolated from roflumilast crude^[1].

4-Difluoromethoxy-3-hydroxybenzaldehyde is a phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335-H411
• Precautionary statements: P261-P273-P305+P351+P338
• target organs: Respiratory system
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-51-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 2913000090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral; Aquatic Chronic 2; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3
• REACH Registrations: Active