Diethyl Ethoxymethylidenemalonate , ≥98.0%(GC) , 87-13-8

Synonym(s):
DEEMM;Diethyl ethoxymethylenemalonate;Ethoxymethylenemalonic acid diethyl ester

CAS NO.：87-13-8

Empirical Formula: C10H16O5

Molecular Weight: 216.23

MDL number: MFCD00009148

EINECS: 201-725-7

PRODUCT Properties

• Melting point: -33°C
• Boiling point: 279-283 °C(lit.)
• Density: 1.080 g/mL at 20 °C(lit.)
• vapor pressure: <0.1 hPa
• refractive index: n20/D 1.463
• Flash point: 311 °F
• storage temp.: Store below +30°C.
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• form: Liquid
• color: Clear colorless to light yellow
• Water Solubility: insoluble
• BRN: 880058
• InChIKey: LTMHNWPUDSTBKD-UHFFFAOYSA-N
• LogP: 1.5-2.1 at pH7
• CAS DataBase Reference: 87-13-8(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8)
• EPA Substance Registry System: Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8)

Description and Uses

Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H315-H317-H319-H410
• Precautionary statements: P261-P273-P280-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38-42/43
• Safety Statements: 26-36/37/39-27-24/25
• WGK Germany: 1
• RTECS: OO1100000
• Autoignition Temperature: 215 °C
• TSCA: Yes
• HS Code: 29189090
• Toxicity: LD50 orally in Rabbit: 925 mg/kg LD50 dermal Rat > 2000 mg/kg