DMOG , ≥98%(HPLC) , 89464-63-1

Synonym(s):
Dimethyloxalylglycine;HIF-Hydroxylase Inhibitor, DMOG - CAS 89464-63-1 - Calbiochem;N-(Methoxyoxoacetyl)-glycine methyl ester;N-(Methoxyoxoacetyl)-glycine methyl ester, Dimethyloxalylglycine, HIF Prolyl Hydroxylase Inhibitor I, HIF Aspartyl β-Hydroxylase Inhibitor, HIF Asparanginyl β-Hydroxylase Inhibitor

CAS NO.：89464-63-1

Empirical Formula: C6H9NO5

Molecular Weight: 175.14

MDL number: MFCD05865098

EINECS: 200-256-5

PRODUCT Properties

• Melting point: 46-48°C
• Boiling point: 179-182 °C(Press: 12 Torr)
• Density: 1.246±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: H2O: >30mg/mL
• form: Solid
• pka: 10.55±0.46(Predicted)
• color: white to off-white
• Water Solubility: Soluble in water at 30mg/ml.
• Stability: Stable for 2 years from date of purchase as supplied. Solutions are not stable. Solutions must be made fresh and used within 1 working day.
• InChI: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
• InChIKey: BNJOZDZCRHCODO-UHFFFAOYSA-N
• SMILES: C(OC)(=O)CNC(C(OC)=O)=O

Description and Uses

The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor that regulates hypoxia-inducible factor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xi,Xn
• Risk Statements: 22
• WGK Germany: 3
• HS Code: 2924.19.8000
• HazardClass: IRRITANT
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral