Rapamycin , ≥95%(HPLC) , 53123-88-9

Synonym(s):
Rapamycin;Sirolimus;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution;mTOR Inhibitor I

CAS NO.：53123-88-9

Empirical Formula: C51H79NO13

Molecular Weight: 914.19

MDL number: MFCD00867594

EINECS: 610-965-5

PRODUCT Properties

• Melting point: 183-185°C
• alpha: D25 -58.2° (methanol)
• Boiling point: 799.83°C (rough estimate)
• Density: 1.0352 (rough estimate)
• vapor pressure: 0.56 hPa ( 20 °C)
• refractive index: 1.5280 (estimate)
• Flash point: 87 °C
• storage temp.: -20°C
• solubility: ethanol: soluble2MM
• pka: 10.40±0.70(Predicted)
• form: solution
• color: colorless to yellow
• Water Solubility: Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
• Sensitive: Moisture Sensitive/Light Sensitive/Hygroscopic
• Merck: 14,8114
• Stability: Stable for 2 years? from date of purchase as supplied.? Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
• CAS DataBase Reference: 53123-88-9(CAS DataBase Reference)

Description and Uses

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities. The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. Rapamycin also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Rapamycin also exhibits Angiogenesis inhibition, possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR. Rapamycin is also known as Rapamune, 23,27-Epoxy-3H-pyrido[2,1-c] oxaazacyclohentriacontine, AY 22989, and mTOR Inhibitor I.

Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa?Nui. Used as an immunosuppressant; antirestenotic. This compound contains aproximately 2% d0.;Labeled Sir

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H351-H361fd
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xi,Xn,F
• Risk Statements: 36/38-36-20/21/22-11
• Safety Statements: 22-24/25-37/39-26-36/37-16
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 2
• RTECS: VE6250000
• Autoignition Temperature: 301 °C
• HS Code: 29349990
• Hazardous Substances Data: 53123-88-9(Hazardous Substances Data)
• Toxicity: LD50 in mice (mg/kg): 600 i.p.; >2,500 orally (Vézina)