Erythromycin , Efficiency ≥850 μg/mg , 114-07-8

Synonym(s):
Erythromycin;USP;Erythromycin A;Erythromycinum;Volumetric flasks

CAS NO.：114-07-8

Empirical Formula: C37H67NO13

Molecular Weight: 733.93

MDL number: MFCD00084654

EINECS: 204-040-1

PRODUCT Properties

• Melting point: 133 °C
• alpha: -74.5 º (c=2, ethanol)
• Boiling point: 719.69°C (rough estimate)
• Density: 1.1436 (rough estimate)
• refractive index: -74 ° (C=2, EtOH)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: ethanol: soluble
• pka: 8.8(at 25℃)
• form: powder
• color: white to faint yellow
• optical activity: [α]/D -78 to --71°
• biological source: Streptomyces erythreus
• Water Solubility: Soluble in water at 2mg/ml
• Merck: 14,3681
• BRN: 8183758
• Major Application: pharmaceutical (small molecule)
• InChIKey: HIYRERIGRWIODP-PNFGZDISSA-N
• EPA Substance Registry System: Erythromycin (114-07-8)

Description and Uses

Erythromycin ethyl succinate is a mixed double ester pro-drug in which one carboxyl of succinic acid esterifies the C-2′ hydroxyl of erythromycin and the other ethanol. This pro-drug frequently is used in an oral suspension for pediatric use largely to mask the bitter taste of the drug. Film-coated tablets also are used to deal with this. Some cholestatic jaundice is associated with the use of EES.

Macrolide antibacterial

Safety

• Symbol(GHS): GHS02,GHS08
• Signal word: Warning
• Hazard statements: H225-H333-H371
• Precautionary statements: P210-P260-P280a-P303+P361+P353-P405-P501a
• Hazard Codes: Xn,Xi
• Risk Statements: 42/43-36/37/38
• Safety Statements: 45-37-24-36-26-24/25
• WGK Germany: 2
• RTECS: KF4375000
• F: 3-4.3-10
• HazardClass: 3
• HS Code: 29415000
• Storage Class: 11 - Combustible Solids
• Hazardous Substances Data: 114-07-8(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 4600mg/kg
• REACH Registrations: Active