(±)-Epichlorohydrin , AR , 106-89-8
Synonym(s):
(±)-2-(Chloromethyl)oxirane;1-Chloro-2,3-epoxypropane
CAS NO.：106-89-8
Empirical Formula: C3H5ClO
Molecular Weight: 92.52
MDL number: MFCD00005132
EINECS: 203-439-8
PRODUCT Properties
| Melting point: | -57 °C |
| alpha | -1～+1°(D/20℃)(c=1,CH3OH) |
| Boiling point: | 115-117 °C(lit.) |
| Density | 1.183 g/mL at 25 °C(lit.) |
| vapor density | 3.2 (vs air) |
| vapor pressure | 13.8 mm Hg ( 21.1 °C) |
| refractive index | n |
| Flash point: | 93 °F |
| storage temp. | Store below +30°C. |
| solubility | 65.9g/l |
| form | Liquid |
| color | APHA: ≤20 |
| Specific Gravity | 1.183 (20/4℃) |
| Odor | Pungent, garlic; sweet, pungent; like chloroform. |
| explosive limit | 3.8-21%(V) |
| Water Solubility | 6 g/100 mL (10 ºC) |
| FreezingPoint | -57.2℃ |
| Merck | 14,3611 |
| BRN | 79785 |
| Henry's Law Constant | 3.42(x 10-5 atmm3/mol) at 25 °C (static headspace-GC, Welke et al., 1998) |
| Dielectric constant | 22.9（20℃） |
| Exposure limits | TLV-TWA(skin) 8 mg/m3
(2 ppm) (ACGIH);
STEL (15 min) 19 mg/m3
(5 ppm) (NIOSH). |
| Stability: | Unstable. Flammable - note wide explosion limits and low flash point. |
| Major Application | cleaning products cosmetics environmental food and beverages personal care |
| InChI | 1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2 |
| InChIKey | BRLQWZUYTZBJKN-UHFFFAOYSA-N |
| SMILES | ClCC1CO1 |
| LogP | 0.45 at 20℃ |
| CAS DataBase Reference | 106-89-8(CAS DataBase Reference) |
| IARC | 2A (Vol. 11, Sup 7, 71) 1999 |
| NIST Chemistry Reference | Oxirane, (chloromethyl)-(106-89-8) |
| EPA Substance Registry System | Epichlorohydrin (106-89-8) |
Description and Uses
Epoxy resins of the bisphenol A type are synthesized from epichlorhydrin and bisphenol A. This leads to bisphenol-A diglycidyl ether, which is the monomer of bisphenol-A-based epoxy resins. Sensitization to epichlorhydrin occurs mainly in workers in the epoxy-resin industry. Sensitization in individuals not working at epoxy resin plants is rare. It has however been described to occur after contact with a soil fumigant, due to solvent cement and in a worker in a pharmaceutical plant, in a division for drug synthesis. Epichlorhydrin was used for the production of both drugs propranolol and oxprenolol.
Epichlorohydrin is used to make glycerol,epoxy resins, adhesive, and castings; asderivatives for producing dyes, pharmaceu-ticals, surfactants, and plasticizers; and asa solvent for resins, gums, paints, andvarnishes.
Safety
| Symbol(GHS) |     GHS02,GHS05,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H226-H301+H311+H331-H314-H317-H350 |
| Precautionary statements | P201-P210-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter |
| Hazard Codes | T |
| Risk Statements | 45-10-23/24/25-34-43 |
| Safety Statements | 53-45 |
| RIDADR | UN 2023 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TX4900000 |
| Autoignition Temperature | 779 °F |
| TSCA | TSCA listed |
| HS Code | 2910 30 00 |
| HazardClass | 6.1 |
| PackingGroup | II |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Carc. 1B Eye Dam. 1 Flam. Liq. 3 Repr. 2 Skin Corr. 1B Skin Sens. 1 |
| Hazardous Substances Data | 106-89-8(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 0.09 g/kg (Smyth, Carpenter) |
| IDLA | 75 ppm |
