A3962612
4-Ethoxyaniline , 98% , 156-43-4
Synonym(s):
p-Phenetidine;4-Ethoxyaniline
CAS NO.：156-43-4
Empirical Formula: C8H11NO
Molecular Weight: 137.18
MDL number: MFCD00007865
EINECS: 205-855-5
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 2-5 °C(lit.) |
| Boiling point: | 250 °C(lit.) |
| Density | 1.065 g/mL at 25 °C(lit.) |
| vapor pressure | 2.93Pa at 25℃ |
| refractive index | n |
| Flash point: | 240 °F |
| storage temp. | 2-8°C |
| solubility | 20g/l |
| form | A liquid |
| pka | 5.2(at 28℃) |
| color | Clear Yellow |
| PH | 8 (1g/l, H2O, 20℃) |
| Water Solubility | practically insoluble |
| Sensitive | Air Sensitive |
| Merck | 14,7228 |
| BRN | 606666 |
| Dielectric constant | 7.3（21℃） |
| Stability: | Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions | HAIR DYEING |
| InChI | 1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3 |
| InChIKey | IMPPGHMHELILKG-UHFFFAOYSA-N |
| SMILES | CCOc1ccc(N)cc1 |
| CAS DataBase Reference | 156-43-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Ethoxyaniline(156-43-4) |
| EPA Substance Registry System | p-Phenetidine (156-43-4) |
Description and Uses
A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.
Safety
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H331-H302-H313-H316-H319-H361-H372-H317-H341-H411 |
| Precautionary statements | P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P302+P352-P312-P391-P337+P313-P305+P351+P338-P362+P364-P333+P313-P301+P312+P330-P304+P340+P311-P403+P233-P405 |
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | T,Xi,Xn |
| Risk Statements | 23/24/25-33-68-43-36-20/21/22 |
| Safety Statements | 28-36/37-45-46 |
| RIDADR | UN 2311 (PHENETIDINES) |
| WGK Germany | 1 |
| RTECS | SI6465500 |
| F | 8-10 |
| Hazard Note | Irritant |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29222200 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Muta. 2 Skin Sens. 1 |
| Toxicity | LD50 orl-rat: 580 mg/kg GISAAA 35(8),28,70 |
| REACH Registrations | Active |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
