Elesclomol (STA-4783) , ≥98% , 488832-69-5

Synonym(s):
1,3-bis[2-Methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid;N′1,N′3-Dimethyl-N′1,N′3-di(phenylcarbonothioyl)malonohydrazide

CAS NO.：488832-69-5

Empirical Formula: C19H20N4O2S2

Molecular Weight: 400.52

MDL number: MFCD12911784

PRODUCT Properties

• Density: 1.313
• storage temp.: Store at -20°C
• solubility: insoluble in H2O; ≥20.15 mg/mL in DMSO; ≥5.68 mg/mL in EtOH with gentle warming and ultrasonic
• form: solid
• pka: 7.99±0.70(Predicted)
• color: Light yellow to yellow
• InChI: InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)
• InChIKey: BKJIXTWSNXCKJH-UHFFFAOYSA-N
• SMILES: C1=CC(C(=S)N(C)NC(=O)CC(=O)NN(C)C(=S)C2C=CC=CC=2)=CC=C1

Description and Uses

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research[1][2][3][4].

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313