Tigecycline , ≥96% , 220620-09-7

Synonym(s):
9- t-Butylglycylamido-minocycline;9-t-Butylglycylamido-minocycline;9-tert-Butylglycylamidominocycline;Tigecycline;Tigecycline - CAS 220620-09-7 - Calbiochem

CAS NO.：220620-09-7

Empirical Formula: C29H39N5O8

Molecular Weight: 585.65

MDL number: MFCD00935753

EINECS: 685-736-6

PRODUCT Properties

• Melting point: 164-166°C
• Boiling point: 890.9±65.0 °C(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to at least 25 mg/ml).
• pka: 4.50±1.00(Predicted)
• form: Orange powder
• color: Orange
• Merck: 14,9432
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• InChIKey: FPZLLRFZJZRHSY-HJYUBDRYSA-N
• SMILES: C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C(N(C)C)=CC(NC(CNC(C)(C)C)=O)=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
• CAS DataBase Reference: 220620-09-7(CAS DataBase Reference)

Description and Uses

The emergence of drug-resistant bacteria has diminished the clinical utility of the tetracyclines. Research to circumvent the efflux and ribosomal protection mechanisms of bacteria has led to the development of the glycylcyclines. Tigecycline is the first glycylcycline antibiotic to launch for the parenteral treatment of baterial infection, including complicated intra-abdominal and skin infections. Its mechanism of action involves inhibiting protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome to effectively prevent incorporation of amino acid residues into elongating peptide chains. Presumably, ribosomal protection proteins are ineffective against tigecycline due to its higher affinity for ribosomal binding compared to tetracyclines (approximately 16-fold). In addition, tigecycline may be resistant to efflux mechanisms by either their inability to translocate it across the cytoplasmic membrane due to steric complications or simply by their failure to recognize the molecule.

A broad spectrum glycylcycline antibiotic

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H319-H360D-H372-H410
• Precautionary statements: P202-P260-P264-P273-P305+P351+P338-P308+P313
• Safety Statements: 24/25
• RIDADR: 3077
• RTECS: QI7619500
• HazardClass: 9
• PackingGroup: III
• HS Code: 29419090
• Hazardous Substances Data: 220620-09-7(Hazardous Substances Data)