Fmoc-Pen(Trt)-OH , 97% , 201531-88-6

Synonym(s):
Fmoc-α, α-dimethyl-Cys(Trt)-OH,Fmoc-S-trityl-L-penicillamine;Fmoc-β,β-dimethyl-Cys(Trt)-OH;Fmoc-S-trityl-L-penicillamine;Fmoc-Pen(Trt)-OH

CAS NO.：201531-88-6

Empirical Formula: C39H35NO4S

Molecular Weight: 613.76

MDL number: MFCD00237388

PRODUCT Properties

• Boiling point: 768.8±60.0 °C(Predicted)
• alpha: 33 º (c=1 in methanol)
• Density: 1.242±0.06 g/cm3(Predicted)
• storage temp.: Store at -15°C to -25°C.
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• form: Powder
• pka: 3.70±0.10(Predicted)
• color: White to off-white
• optical activity: [α]/D +33±2°, c = 1 in methanol
• InChIKey: XSGMGAINOILNJR-PGUFJCEWSA-N
• SMILES: C(O)(=O)[C@H](C(SC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
• CAS DataBase Reference: 201531-88-6(CAS DataBase Reference)

Description and Uses

Fmoc-S-trityl-L-penicillamine is a coordination compound that contains a thiolate and amide group. It has been used as a model system for studying the interaction between proteins and metal ions, with the cyclic structure mimicking the active site of enzymes. The coordination of Fmoc-S-trityl-L-penicillamine to proteins is affected by trypsin, an enzyme that cleaves peptides at carboxyl side chains. Trypsin can also lead to dehydration of Fmoc-S-trityl-L-penicillamine, forming an eliminations product. This compound also reacts with lysine residues in proteins, resulting in an alkene byproduct that can be removed by hydrogenation.

Fmoc-s-trityl-l-penicillamine is a new peptidomimetic furin inhibitors with potent anti-infectious activity.

Safety

• Hazard statements: H413
• WGK Germany: 3
• HS Code: 2930 90 16
• HazardClass: IRRITANT