Formoterol Hemifumarate , ≥99% , 43229-80-7

Synonym(s):
((±)-2′-Hydroxy-5′-[(R*)-1-hydroxy-2-[[(R*)-p-methoxy-a-methylphenethyl]amino]ethyl]formanilide fumarate (2:1) (salt) dihydrate;Formoterol fumarate dihydrate

CAS NO.：43229-80-7

Empirical Formula: C42H52N4O12

Molecular Weight: 804.88

MDL number: MFCD03093863

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 138-140°C
• storage temp.: Room temperature
• solubility: Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
• form: Solid
• pka: pKa1 7.9; pKa2 9.2(at 25℃)
• color: White to off-white
• λmax: 284nm(lit.)
• Merck: 14,4245
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• Major Application: pharmaceutical
• InChIKey: OBRNDARFFFHCGE-WXXKFALUSA-N
• SMILES: N(C(Cc4ccc(cc4)OC)C)CC(O)c3cc(c(cc3)O)NC=O.N(C(Cc2ccc(cc2)OC)C)CC(O)c1cc(c(cc1)O)NC=O.OC(=O)\C=C\C(=O)O

Description and Uses

Formoterol fumarate is a β2-selective adrenergic agonist useful in the treatment of bronchial asthma. It s potency and duration of action a r e reported to exceed those of salbutamol, as is its ability to inhibit allergic and non-allergic histamine release.

Formoterol fumarate is a potent β2-AR agonist.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H361d-H370-H373-H412
• Precautionary statements: P201-P202-P260-P264-P273-P301+P310
• RIDADR: 3249
• WGK Germany: WGK 3
• RTECS: LQ2988000
• HazardClass: 6.1(b)
• PackingGroup: II
• Storage Class: 6.1C - Combustible acute toxic Cat.3; toxic compounds or compounds which causing chronic effects
• Hazard Classifications: Acute Tox. 4 Inhalation; Aquatic Chronic 3; Repr. 2; STOT RE 2; STOT SE 1
• Toxicity: LD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida)