Fluticasone propionate , ≥97% , 80474-14-2

Synonym(s):
(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;Fluticasone propionate

CAS NO.：80474-14-2

Empirical Formula: C25H31F3O5S

Molecular Weight: 500.57

MDL number: MFCD00866007

EINECS: 617-082-4

PRODUCT Properties

• Melting point: 275 °C
• alpha: D +30° (c = 0.35)
• Boiling point: 568.3±50.0 °C(Predicted)
• Density: 1.32±0.1 g/cm3(Predicted)
• refractive index: 31 ° (C=1, Dioxane)
• storage temp.: Store at RT
• solubility: DMSO: ≥10 mg/mL
• form: solid
• pka: 12.53±0.70(Predicted)
• color: white
• Merck: 14,4211
• InChIKey: WMWTYOKRWGGJOA-CENSZEJFSA-N
• SMILES: [C@]1(C(=O)SCF)(OC(=O)CC)[C@H](C)C[C@@]2([H])[C@]3([H])C[C@@H](C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)F |&1:0,11,14,16,19,26,28,30,33,r|
• CAS DataBase Reference: 80474-14-2(CAS DataBase Reference)
• EPA Substance Registry System: Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-,S-(fluoromethyl) ester, (6.alpha.,11.beta.,16.alpha.,17.alpha.)- (80474-14-2)

Description and Uses

Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects, due to its low systemic bioavailability.

Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma. Fluticasone Proprionate is marketed under several different brand names such as Flonase(R). Fluticasone propionate is also available as a combination product of Azelastine Hydrochloride and Fluticasone Propionate called Dymista(TM). Dymista(TM) is indicated in patients over 12 years old for symptomatic relief of seasonal allergic rhinitis.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361fd-H373
• Precautionary statements: P260-P308+P313-P281
• Safety Statements: 22-24/25
• WGK Germany: 2
• RTECS: BV7980000
• HS Code: 29372900
• Toxicity: LD50 oral in rat: > 2gm/kg