4-Fluorophenylmagnesium bromide solution , 1.0MinMeTHF , 352-13-6

CAS NO.：352-13-6

Empirical Formula: C6H4BrFMg

Molecular Weight: 199.31

MDL number: MFCD00009667

EINECS: 627-087-3

PRODUCT Properties

• Melting point: 5 °C
• Boiling point: 66°C
• Density: 1.043 g/mL at 25 °C
• Flash point: −40 °F
• storage temp.: Flammables + water-Freezer (-20°C)e area
• form: Solution
• color: Clear yellow to red-brown
• Water Solubility: It reacts violently with water.
• Sensitive: Air & Moisture Sensitive
• BRN: 636802
• InChI: InChI=1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1
• InChIKey: QYBFFRXNNFXREA-UHFFFAOYSA-M
• SMILES: [Mg](C1=CC=C(F)C=C1)Br
• CAS DataBase Reference: 352-13-6
• EPA Substance Registry System: Magnesium, bromo(4-fluorophenyl)- (352-13-6)

Description and Uses

4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:

• Useful key intermediate in the synthesis of paroxetine.
• Arylsulfides via cross-coupling reaction with thiols.
• 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
• Grignard intermediate for preparing aprepitant.

Safety

• Symbol(GHS): GHS02,GHS05,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H225-H302-H314-H335-H351-H336-H318-H371-H372
• Precautionary statements: P233-P240-P241+P242+P243-P264-P270-P271-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P308+P311-P403+P233-P405-P501-P260h-P303+P361+P353-P501a-P210-P260-P280-P305+P351+P338-P370+P378-P403+P235-P261-P310
• Hazard Codes: F+,C,F
• Risk Statements: 12-14-22-34-66-67-11-40-37-19
• Safety Statements: 16-26-36/37/39-43-45-7/8-33-8-7
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• F: 10-21
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• HS Code: 29319090
• Limited Quantities: 1.0 L (0.3 gallon) (liquid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)