trans-Nerolidol , ≥85% , 40716-66-3
Synonym(s):
3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol;3-Hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene;Nerolidol
CAS NO.：40716-66-3
Empirical Formula: C15H26O
Molecular Weight: 222.37
MDL number: MFCD00008911
EINECS: 255-053-4
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB266.40 | In Stock |
|
| 1g | RMB379.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 145-146 °C12 mm Hg(lit.) |
| Density | 0.876 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 230 °F |
| storage temp. | -20°C |
| solubility | DMF: miscible,DMSO: miscible,Ethanol: miscible,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml |
| form | Liquid |
| pka | 14.40±0.29(Predicted) |
| color | Colorless to light yellow |
| Odor | at 100.00 %. floral green citrus woody waxy |
| Odor Type | floral |
| JECFA Number | 1646 |
| Merck | 13,6501 |
| BRN | 5731231 |
| Stability: | Light Sensitive |
| Major Application | food and beverages |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C15H26O/c1-6-15(5,16)12-8-11-14(4)10-7-9-13(2)3/h6,9,11,16H,1,7-8,10,12H2,2-5H3/b14-11+ |
| InChIKey | FQTLCLSUCSAZDY-SDNWHVSQSA-N |
| SMILES | C\C(C)=C/CC\C(C)=C\CCC(C)(O)C=C |
| LogP | 5.316 (est) |
| NIST Chemistry Reference | 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (e)-(40716-66-3) |
Description and Uses
trans-Nerolidol is a sesquiterpene that has been found in various plants, including C. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties. In a disc assay, trans-nerolidol inhibits the growth of S. aureus, B. subtilis, E. coli, and S. cerevisiae with zones of inhibition measuring 10, 9, 10, and 4 mm, respectively. It reduces viability of CaCo-2 adenocarcinoma cells with an IC50 value of 28.7 mg/L and reduces production of reactive oxygen species (ROS). trans-Nerolidol is insecticidal against A. aegypti larvae with a 24-hour LC50 value of 9 mg/L.
Nerolidol (cas# 40716-66-3) is a terpene standard found in cannabis.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H317-H319-H410 |
| Precautionary statements | P261-P264-P273-P280-P302+P352-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| F | 10-23 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Sens. 1B |
| Toxicity | Both the acute oral LD50 in rats and the acute dermal LD50 in rabbits exceeded 5 g/kg (Russell. 1973). |
