L-Glutamic acid γ-benzyl ester , 98% , 1676-73-9

Synonym(s):
L-Glutamic acid 5-benzyl ester

CAS NO.：1676-73-9

Empirical Formula: C12H15NO4

Molecular Weight: 237.25

MDL number: MFCD00002633

EINECS: 216-826-1

PRODUCT Properties

• Melting point: 181-182 °C(lit.)
• alpha: 27.2 º (c=2, 1N HCL)
• Boiling point: 379.78°C (rough estimate)
• Density: 1.2026 (rough estimate)
• refractive index: 1.5200 (estimate)
• storage temp.: 2-8°C
• solubility: Acetic Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
• form: Powder
• pka: 2.20±0.10(Predicted)
• color: White
• optical activity: [α]20/D +19±2°, c = 1% in acetic acid
• BRN: 1885646
• InChI: InChI=1S/C12H15NO4/c13-10(12(15)16)6-7-11(14)17-8-9-4-2-1-3-5-9/h1-5,10H,6-8,13H2,(H,15,16)/t10-/m0/s1
• InChIKey: BGGHCRNCRWQABU-JTQLQIEISA-N
• SMILES: C(O)(=O)[C@H](CCC(OCC1=CC=CC=C1)=O)N
• CAS DataBase Reference: 1676-73-9(CAS DataBase Reference)
• EPA Substance Registry System: L-Glutamic acid, 5-(phenylmethyl) ester (1676-73-9)

Description and Uses

L-Glutamic acid γ-benzyl ester is commonly used in the synthesis of polymers for biological applications. Some of the examples are:

• Synthesis of bioreducible block copolymers based on poly(ethylene glycol) and poly(γ-benzyl L-glutamate) for Intracellular drug delivery.
• Synthesis of biodegradable poly(L-glutamic acid)-b-polylactide for magnetic resonance imaging (MRI)-visible drug delivery system.
• Synthesis of pH and temperature-responsive diblock copolymers based on poly(L-glutamic acid).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• HS Code: 29224999