GW5074 , ≥97% , 220904-83-6

Synonym(s):
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one;5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074;Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem

CAS NO.：220904-83-6

Empirical Formula: C15H8Br2INO2

Molecular Weight: 520.94

MDL number: MFCD09971042

PRODUCT Properties

• Boiling point: 561.4±50.0 °C(Predicted)
• Density: 2.248±0.06 g/cm3(Predicted)
• storage temp.: room temp
• solubility: DMSO: soluble
• form: solid
• pka: 5.86±0.25(Predicted)
• color: yellow to orange-brown
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
• InChI: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)
• InChIKey: LMXYVLFTZRPNRV-XCVCLJGOSA-N
• SMILES: N1C2=C(C=C(I)C=C2)C(=CC2=CC(Br)=C(O)C(Br)=C2)C1=O
• CAS DataBase Reference: 220904-83-6

Description and Uses

GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• HS Code: 2933790090