Gemfibrozil , ≥99% , 25812-30-0
Synonym(s):
2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid;2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid;5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
CAS NO.：25812-30-0
Empirical Formula: C15H22O3
Molecular Weight: 250.33
MDL number: MFCD00079335
EINECS: 247-280-2
| Pack Size | Price | Stock | Quantity |
| 5G | RMB73.60 | In Stock |
|
| 25G | RMB210.40 | In Stock |
|
| 100G | RMB680.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 61-63°C |
| Boiling point: | 158-159 C |
| Density | 1.1109 (rough estimate) |
| refractive index | 1.5020 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, very soluble in methylene chloride, freely soluble in anhydrous ethanol and in methanol. |
| form | powder |
| pka | 4.75±0.45(Predicted) |
| color | White to Off-White |
| Water Solubility | >0.5g/L(temperature not stated) |
| Merck | 14,4388 |
| BCS Class | 2 |
| Major Application | forensics and toxicology pharmaceutical (small molecule) |
| InChI | 1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17) |
| InChIKey | HEMJJKBWTPKOJG-UHFFFAOYSA-N |
| SMILES | Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1 |
| CAS DataBase Reference | 25812-30-0(CAS DataBase Reference) |
| IARC | 3 (Vol. 66) 1996 |
| EPA Substance Registry System | Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- (25812-30-0) |
Description and Uses
Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 μM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.
This drug is used for hyperlipoproteinemia that cannot be corrected by a special diet or by physical exertion.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-63-62-46-36/38-21 |
| Safety Statements | 36-53-36/37-26-25 |
| WGK Germany | 3 |
| RTECS | YV7120000 |
| HazardClass | IRRITANT |
| HS Code | 2918992090 |
| Storage Class | 13 - Non Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Hazardous Substances Data | 25812-30-0(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz) |
