Gimeracil , ≥98% , 103766-25-2

Synonym(s):
5-chloro-4-hydroxypyridin-2(1H)-one;5-Chloropyridine-2,4-diol;CDHP;Gimestat

CAS NO.：103766-25-2

Empirical Formula: C5H4ClNO2

Molecular Weight: 145.54

MDL number: MFCD08458352

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 274 °C
• Boiling point: 255.1±40.0 °C(Predicted)
• Density: 1.56±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 5 mg/ml).
• form: solid
• pka: 4.50±1.00(Predicted)
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChI: InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9)
• InChIKey: ZPLQIPFOCGIIHV-UHFFFAOYSA-N
• SMILES: C1(=O)NC=C(Cl)C(O)=C1
• CAS DataBase Reference: 103766-25-2(CAS DataBase Reference)

Description and Uses

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor. DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2 Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Safety Statements: 24/25
• WGK Germany: WGK 3
• HS Code: 29337900
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral