ChonglousaponinI , 97% , 50773-41-6
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB159.20 | In Stock |
|
| 25mg | RMB639.20 | In Stock |
|
| 100mg | RMB1999.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >245°C (dec.) |
| Density | 1.40 |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) |
| pka | 12?+-.0.70(Predicted) |
| form | Solid |
| color | White |
Description and Uses
Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.
Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| HS Code | 29389090 |
