N-Hydroxysuccinimide , 98% , 6066-82-6
Synonym(s):
1-Hydroxy-2,5-pyrrolidinedione;HOSu;NHS;N-Hydroxysuccinimide;N-Hydroxysuccinimide, NHS
CAS NO.：6066-82-6
Empirical Formula: C4H5NO3
Molecular Weight: 115.09
MDL number: MFCD00005516
EINECS: 228-001-3
| Pack Size | Price | Stock | Quantity |
| 5g | RMB23.20 | In Stock |
|
| 25G | RMB27.20 | In Stock |
|
| 100G | RMB64.00 | In Stock |
|
| 500G | RMB226.40 | In Stock |
|
| 2.5KG | RMB986.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 95-98 °C(lit.) |
| Boiling point: | 215.33°C (rough estimate) |
| Density | 1.4769 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4080 (estimate) |
| storage temp. | Store at +2°C to +8°C. |
| solubility | DMSO (Soluble), Methanol (Slightly) |
| pka | 7.81±0.20(Predicted) |
| form | Liquid or Solid |
| color | Clear yellow-brown to brown |
| PH | 5-7 (50g/l, H2O, 20℃) |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 113913 |
| Stability: | Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
| LogP | -2.01 |
| CAS DataBase Reference | 6066-82-6(CAS DataBase Reference) |
| NIST Chemistry Reference | N-hydroxylsuccinimide(6066-82-6) |
| EPA Substance Registry System | 2,5-Pyrrolidinedione, 1-hydroxy- (6066-82-6) |
Description and Uses
N-hydroxysuccinimide is a synthetic ingredient used in cosmetics as an ester to soften and condition skin. It's also a reagent, a substance used to trigger a reaction that leads to a new substance, such as peptides and polymers.
N-Hydroxysuccinimide is used in cosmetics and beauty products as an ester often seen in eye creams. N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. "Infra-orbital shadows are due to the accumulation of hemoglobin and its coloured degradation products - biliverdin, bilirubin and iron - in the dermis and epidermis ... N-hydroxysuccinimide renders the iron soluble for natural elimination" (source).
N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H315-H318 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-26-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29251995 |
