Hederagenin , Analysis of standard products, ≥98% , 465-99-6
Synonym(s):
3,23-Dihydroxyolean-12-en-28-acid;Astrantiagenin E;Caulosapogenin;Hederagenic acid;Hederagenol
CAS NO.：465-99-6
Empirical Formula: C30H48O4
Molecular Weight: 472.71
MDL number: MFCD00017385
EINECS: 207-369-9
| Pack Size | Price | Stock | Quantity |
| 50mg | RMB375.20 | In Stock |
|
| 250mg | RMB1279.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 332-334° |
| alpha | D20 +81° (c = 0.7 in pyridine) |
| Boiling point: | 493.44°C (rough estimate) |
| Density | 0.9871 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | methanol: soluble1mg/mL |
| pka | 4.63±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| λmax | 405nm(H2SO4)(lit.) |
| Merck | 14,4624 |
| InChIKey | PGOYMURMZNDHNS-MYPRUECHSA-N |
| SMILES | C[C@@]12CC[C@]3(CCC(C)(C)C[C@@]3([H])C1=CC[C@]1([H])[C@]3(CC[C@H](O)[C@@](C)(CO)[C@]3([H])CC[C@@]21C)C)C(=O)O |&1:1,4,11,16,18,21,23,27,31,r| |
| LogP | 7.410 (est) |
Description and Uses
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312+P330-P501 |
| Hazard Codes | Xi |
| Risk Statements | 22 |
| Safety Statements | 22-45-24/25 |
| WGK Germany | 3 |
| HS Code | 29181990 |
