4-Hydroxy-2-methylquinoline , 98% , 607-67-0

Synonym(s):
2-Methyl-4-quinolinol

CAS NO.：607-67-0

Empirical Formula: C10H9NO

Molecular Weight: 159.18

MDL number: MFCD00006758

EINECS: 210-140-6

PRODUCT Properties

• Melting point: 234-236 °C(lit.)
• Boiling point: 284.68°C (rough estimate)
• Density: 1.1202 (rough estimate)
• refractive index: 1.6070 (estimate)
• storage temp.: Sealed in dry,Room Temperature
• form: powder to crystal
• pka: 4.44±0.40(Predicted)
• color: White to Light yellow
• Water Solubility: Slightly soluble in water.
• λmax: 317nm(CHCl3)(lit.)
• BRN: 118320
• InChI: InChI=1S/C10H9NO/c1-7-6-10(12)8-4-2-3-5-9(8)11-7/h2-6H,1H3,(H,11,12)
• InChIKey: NWINIEGDLHHNLH-UHFFFAOYSA-N
• SMILES: N1C2C(=CC=CC=2)C(O)=CC=1C
• LogP: 1.902 (est)
• CAS DataBase Reference: 607-67-0(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinolinol, 2-methyl-(607-67-0)

Description and Uses

4-Hydroxy-2-methylquinoline can be used as an intermediate in the synthesis of a wide range of medicinally important compounds such as:

• Synthesis of 2-(quinolin-4-yloxy)acetamides as potent antitubercular agents.
• Synthesis of 2-arylethenylquinoline derivatives for the treatment of Alzheimer′s disease.
• Synthesis of 1,10-diethoxy-1H-pyrano[4,3-b]quinolones as antibacterial agents.
• Synthesis of phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phophodiesterase 10A (PDE10A) inhibitors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39-36/37/39-22
• WGK Germany: 3
• HS Code: 29334900