23-Hydroxybetulinicacid , 85999-40-2
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB399.20 | In Stock |
|
| 25mg | RMB1199.20 | In Stock |
|
| 100mg | RMB3199.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >293°C (dec.) |
| Boiling point: | 585.8±25.0 °C(Predicted) |
| Density | 1.106 |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Methanol (Slightly, Heated), Pyridine (Slightly) |
| form | Solid |
| pka | 4.60±0.70(Predicted) |
| color | White |
| InChIKey | HXWLKAXCQLXHML-WGOZWDAUSA-N |
| SMILES | C([C@]12CC[C@H]([C@]1([H])[C@@]1([H])CC[C@]3([H])[C@]4(CC[C@@H]([C@@]([C@]4([H])CC[C@]3([C@@]1(CC2)C)C)(C)CO)O)C)C(=C)C)(=O)O |
Description and Uses
23-hydroxy Betulinic acid is a triterpenoid that has been found in P. chinensis and has anticancer activity. It inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 μM, respectively), as well as human umbilical vein endothelial cells (HUVECs; IC50 = 94.8 μM). It halts the cell cycle at the S phase and induces apoptosis in K562 cells in a concentration-dependent manner with a loss of the mitochondrial membrane potential and an increase in Bax and cytochrome C protein levels.
23-Hydroxybetulinic Acid is a potential cytoxic agent in the treatment of cancer. Apoptotic effect. Antiproliferative.
