4-Hydroxy-3-methoxyphenylacetic Acid , >98.0%(HPLC) , 306-08-1

Synonym(s):
4-Hydroxy-3-methoxyphenylacetic acid;HVA

CAS NO.：306-08-1

Empirical Formula: C9H10O4

Molecular Weight: 182.17

MDL number: MFCD00004350

EINECS: 206-176-7

PRODUCT Properties

• Melting point: 142-145 °C(lit.)
• Boiling point: 235.56°C (rough estimate)
• Density: 1.1634 (rough estimate)
• refractive index: 1.4209 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• form: Crystalline Powder
• pka: 4.39±0.10(Predicted)
• color: White to beige
• Water Solubility: soluble
• Merck: 14,4740
• BRN: 2213447
• Stability: Hygroscopic
• LogP: 0.330
• CAS DataBase Reference: 306-08-1(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 4-hydroxy-3-methoxy-(306-08-1)
• EPA Substance Registry System: Homovanillic acid (306-08-1)

Description and Uses

Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.

A neuroendocrine tumor marker. Dihydroxyphenylacetic Acid (DOPAC) metabolite.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• TSCA: T
• HazardClass: IRRITANT
• HS Code: 29189900