Hematoporphyrin dihydrochloride , 90% , 17696-69-4
CAS NO.：17696-69-4
Empirical Formula: C34H39ClN4O6
Molecular Weight: 635.16
MDL number: MFCD00013470
EINECS: 241-699-4
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB216.80 | In Stock |
|
| 1g | RMB607.20 | In Stock |
|
| 5g | RMB2399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Very Dark Red |
| Water Solubility | Insoluble in water. Soluble in pyridine (5%). |
| Merck | 14,4636 |
| BRN | 78957 |
| Stability: | Hygroscopic |
| EPA Substance Registry System | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
Description and Uses
Hematoporphyrin is a photosensitizer. Hematoporphyrin (3 μM) increases oxygen consumption and decreases the respiratory control ratio (RCR) in irradiated isolated rat liver mitochondria. It induces DNA breaks in cell-free assays, but not in human HeLa cervical cancer cells, in a light-dependent manner when used at a concentration of 6 μM. Hematoporphyrin (12 μM) decreases the survival of irradiated, but not non-irradiated, HeLa cells. Hematoporphyrin (5 mg/kg) decreases growth of subcutaneous Yoshida AH-130 hepatoma tumors in rats when administered with radiation.
Endogenous porphyrin formed by the acid hydrolysis of hemoglobin. It is employed as an active pharmaceutical intermediate.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 33 |
| RTECS | TS5505000 |
| TSCA | Yes |
| Toxicity | mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978. |
