1-Iodo-3,5-dimethylbenzene , ≥98.0% , 22445-41-6

Synonym(s):
5-Iodo-m-xylene

CAS NO.：22445-41-6

Empirical Formula: C8H9I

Molecular Weight: 232.06

MDL number: MFCD00060659

EINECS: 629-121-2

PRODUCT Properties

• Melting point: -2.9°C (estimate)
• Boiling point: 92-94 °C3 mm Hg(lit.)
• Density: 1.608 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.594(lit.)
• Flash point: >230 °F
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Sparingly soluble (0.014 g/L) (25°C), Calc.
• form: Liquid
• Specific Gravity: 1.608
• color: Clear light yellow
• Sensitive: Light Sensitive
• BRN: 2039353
• InChIKey: ZLMKEENUYIUKKC-UHFFFAOYSA-N
• CAS DataBase Reference: 22445-41-6(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-iodo-3,5-dimethyl-(22445-41-6)

Description and Uses

1-Iodo-3,5-dimethylbenzene (5-iodo-m-xylene) is suitable for use in the synthesis of N-(3,5-xylyl)-N-ethylaniline, an arylamine.
It may be used in the following studies:

• α-Arylation of ketones.
• Copper-catalyzed N-arylation of imidazoles.
• Cyanation of 5-iodo-m-xylene to form 3,5-dimethylbenzonitrile.
• Synthesis of 1,3-Dimethyl-5-phenoxybenzene by nano-CuFe₂O₄ catalyzed C-O cross-coupling with phenol.
• CuBr-catalyzed amination of 1-iodo-3,5-dimethylbenzene to form N-Allyl-3,5-dimethylbenzenamine.
• Copper-catalyzed C-S bond-formation between 5-iodo-m-xylene and thiophenol.
• As a starting material in the synthesis of biphenyl-3,3′,5,5′-tetracarboxylic acid.
• Radical bromination of 5-iodo-m-xylene by N-bromosuccinimide to form 1,3-bis(bromomethyl)-5-iodobenzene.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi,C
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 29039990