Ispinesib (SB-715992) , ≥98% , 336113-53-2

CAS NO.：336113-53-2

Empirical Formula: C30H33ClN4O2

Molecular Weight: 517.06

MDL number: MFCD22628831

PRODUCT Properties

• Melting point: 89 - 92°C
• Boiling point: 708.0±70.0 °C(Predicted)
• Density: 1.21±0.1 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under inert atmosphere
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: Solid
• pka: 9.65±0.10(Predicted)
• color: White to Off-White
• optical activity: [α]/D +315 to +375°, c =0.5 in chloroform-d
• InChIKey: QJZRFPJCWMNVAV-HHHXNRCGSA-N
• SMILES: C(N(CCCN)[C@@H](C1N(CC2=CC=CC=C2)C(=O)C2=C(N=1)C=C(Cl)C=C2)C(C)C)(=O)C1=CC=C(C)C=C1

Description and Uses

The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins. It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM in colon, pancreas, prostrate, and lung cancer cells in vitro). At 10 mg/kg, ispinesib produces tumor regression of breast cancer cell xenografts in mice. It has also been used to halt the growth of treatment-resistant glioblastoma tumor-initiating cells, to prevent tumor initiation and self-renewal of a cancer stem cell population (EC50 = 1.15 nM), and to reduce glioma cell invasion.[Cayman Chemical]

Safety

• Symbol(GHS): GHS02,GHS05,GHS06,GHS08
• Signal word: Warning
• Hazard statements: H227
• Precautionary statements: P501-P210-P280-P370+P378-P403+P235