IC-87114 , ≥98% , 371242-69-2

Synonym(s):
Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X;PI 3-Kδ Inhibitor X, IC87114 - CAS 371242-69-2 - Calbiochem

CAS NO.：371242-69-2

Empirical Formula: C22H19N7O

Molecular Weight: 397.43

MDL number: MFCD09970845

PRODUCT Properties

• Boiling point: 673.7±65.0 °C(Predicted)
• Density: 1.43
• storage temp.: Store at -20°C
• solubility: insoluble in H2O; insoluble in EtOH; ≥6.62 mg/mL in DMF
• form: White powder solid.
• pka: 3.90±0.10(Predicted)
• color: White to gray
• InChI: 1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)
• InChIKey: GNWHRHGTIBRNSM-UHFFFAOYSA-N
• SMILES: [n]4(c5ncnc(c5nc4)N)Cc1[n]([c](c3c(n1)cccc3C)=O)c2c(cccc2)C
• CAS DataBase Reference: 371242-69-2

Description and Uses

The phosphatidylinositol 3-kinase (PI3K) signaling pathway has central roles in cell growth, development, and survival. IC-87114 is a cell-permeable selective inhibitor of the PI3K catalytic subunit p110δ (IC₅₀ = 0.5 μM). It less effectively inhibits p110γ and p110β (IC₅₀ = 29 and 75 μM, respectively) and has no significant effect on p110α and several other kinases. This product is used to elucidate the role of p110δ in cells, including neutrophils, natural killer cells, and other types of leukocytes. It has also been used in mice.

IC 87114 is a selective PI3Kδ inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
• WGK Germany: WGK 2
• Storage Class: 11 - Combustible Solids